Chromatin damage as anti-cancer approach
Chromatin damaging anti-cancer therapy
What is chromatin damage?
Chromatin damage is the loss of histones from nucleosomes in the absence of chemical modifications of DNA. In many cases, both types of damage are observed together because DNA damage may destabilize nucleosomes, and loss of histones makes DNA more sensitive to chemical modifications. In contrast to DNA damage, the causes and consequences of chromatin damage are poorly studied.
DNA damage is any chemical modification of DNA (e.g., double- and single-strand breaks, base modifications).