Collaborations

Our long-term collaborators are many investigators from Childrens Cancer Institute Australia (CCIA) in Sydney. We have and continue to collaborate on studies aimed at finding novel therapies for pediatric malignancies, such as neuroblastoma with Michelle Haber, Murray Norris and Glenn Marshall, leukemia with Michelle Henderson and Richard Lock, DIPG with David Ziegler.

Here are our mutual papers:

We work together with several researchers in Cleveland Clinic, most of all, with George Stark, who helped us a lot with characterizing of quinacrine and curaxins effect against several different cancers, including NSCLC and glioblastoma.

Here are our common papers:

Our long term and very fruitful collaboration with the lab of Marianna Yakubovskaya at Russian National Cancer Center in Moscow, Russia. They are expert in DNA structure and biology, interactions of small molecules with DNA as well as chemical carcinogenesis. We explore together effect of different non-carcinogenic molecules on DNA and chromatin. Our recent papers are here:

Other recent collaborations

Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation.

Jean MJ, Hayashi T, Huang H, Brennan J, Simpson S, Purmal A, Gurova K, Keefer MC, Kobie JJ, Santoso NG, Zhu J.

Front Microbiol. 2017 Oct 17;8:2007. doi: 10.3389/fmicb.2017.02007. eCollection 2017.

PMID: 29089933 Free PMC Article

Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas.

Kim M, Neznanov N, Wilfong CD, Fleyshman DI, Purmal AA, Haderski G, Stanhope-Baker P, Burkhart CA, Gurova KV, Gudkov AV, Skitzki JJ.

Cancer Res. 2016 Nov 15;76(22):6620-6630. doi: 10.1158/0008-5472.CAN-15-2764. Epub 2016 Sep 28.

PMID: 27680682 Free PMC Article

Novel synthetic cyclic integrin αvβ3 binding peptide ALOS4: Antitumor activity in mouse melanoma models.

Yacobovich S, Tuchinsky L, Kirby M, Kardash T, Agranyoni O, Nesher E, Redko B, Gellerman G, Tobi D, Gurova K, Koman I, Ashur Fabian O, Pinhasov A.

Oncotarget. 2016 Sep 27;7(39):63549-63560. doi: 10.18632/oncotarget.11363.

PMID: 27556860 Free PMC Article

Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.

Barone TA, Burkhart CA, Safina A, Haderski G, Gurova KV, Purmal AA, Gudkov AV, Plunkett RJ.

Neuro Oncol. 2017 Feb 1;19(2):186-196. doi: 10.1093/neuonc/now141.

PMID: 27370399 Free PMC Article

Inhibition of the FACT Complex Reduces Transcription from the Human Cytomegalovirus Major Immediate Early Promoter in Models of Lytic and Latent Replication.

O'Connor CM, Nukui M, Gurova KV, Murphy EA.

J Virol. 2016 Mar 28;90(8):4249-53. doi: 10.1128/JVI.02501-15. Print 2016 Apr.

PMID: 26865717 Free PMC Article

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency.

Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge SJ, Zhu J.

J Biol Chem. 2015 Nov 6;290(45):27297-310. doi: 10.1074/jbc.M115.652339. Epub 2015 Sep 16.

PMID: 26378236 Free PMC Article

Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle.

Erath J, Gallego-Delgado J, Xu W, Andriani G, Tanghe S, Gurova KV, Gudkov A, Purmal A, Rydkina E, Rodriguez A.

Antimicrob Agents Chemother. 2015 Mar;59(3):1427-34. doi: 10.1128/AAC.04704-14. Epub 2014 Dec 15.

PMID: 25512429 Free PMC Article