Publications

Structure and function of histone chaperone FACT – resolving FACTual issues. Katerina Gurova, Han-Wen Chang, Maria Valieva, Poorva Sandlesh, Vasily Studitsky. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1861, Issue 9, September 2018, Pages 892-904

Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.  Poorva Sandlesh, Thierry Juang, Alfiya Safina, Michael J. Higgins, Katerina V. Gurova. PlosONE, 13(6): e0199785. https://doi.org/
10.1371/journal.pone.0199785

 

TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells.

Leonova K, Safina A, Nesher E, Sandlesh P, Pratt R, Burkhart C, Lipchick B, Gitlin I, Frangou C, Koman I, Wang J, Kirsanov K, Yakubovskaya MG, Gudkov AV, Gurova K.

Elife. 2018 Feb 5;7. pii: e30842. doi: 10.7554/eLife.30842.

PMID: 29400649     Free PMC Article

Role of chromatin damage and chromatin trapping of FACT in mediating the anticancer cytotoxicity of DNA-binding small molecule drugs.

Nesher E, Safina A, Aljahdali I, Portwood S, Wang ES, Koman I, Wang J, Gurova KV.

Cancer Res. 2018 Jan 16. pii: canres.2690.2017. doi: 10.1158/0008-5472.CAN-17-2690. [Epub ahead of print]

PMID:  29339544

Prognostic value of histone chaperone FACT subunits expression in breast cancer.

Attwood K, Fleyshman D, Prendergast L, Paszkiewicz G, Omilian AR, Bshara W, Gurova K.

Breast Cancer (Dove Med Press). 2017 May 3;9:301-311. doi: 10.2147/BCTT.S126390. eCollection 2017.

PMID: 28496363    Free PMC Article

Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.

Fleyshman D, Prendergast L, Safina A, Paszkiewicz G, Commane M, Morgan K, Attwood K, Gurova K.

Oncotarget. 2017 Mar 28;8(13):20525-20542. doi: 10.18632/oncotarget.15656.

PMID: 28423528  Free PMC Article 

FACT is a sensor of DNA torsional stress in eukaryotic cells.

Safina A, Cheney P, Pal M, Brodsky L, Ivanov A, Kirsanov K, Lesovaya E, Naberezhnov D, Nesher E, Koman I, Wang D, Wang J, Yakubovskaya M, Winkler D, Gurova K.

Nucleic Acids Res. 2017 Feb 28;45(4):1925-1945. doi: 10.1093/nar/gkw1366.

PMID: 28082391  Free PMC Article

ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin.

Fleyshman D, Cheney P, Ströse A, Mudambi S, Safina A, Commane M, Purmal A, Morgan K, Wang NJ, Gray J, Spellman PT, Issaeva N, Gurova K.

Cell Cycle. 2016;15(3):455-70. doi: 10.1080/15384101.2015.1127478. Epub 2015 Dec 22.

PMID: 26694952

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

Carter DR, Murray J, Cheung BB, Gamble L, Koach J, Tsang J, Sutton S, Kalla H, Syed S, Gifford AJ, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, Ling D, Kim PY, Webber H, Clark A, Ruhle M, Liu B, Oberthuer A, Fischer M, Byrne J, Saletta F, Thwe le M, Purmal A, Haderski G, Burkhart C, Speleman F, De Preter K, Beckers A, Ziegler DS, Liu T, Gurova KV, Gudkov AV, Norris MD, Haber M, Marshall GM.

Sci Transl Med. 2015 Nov 4;7(312):312ra176. doi: 10.1126/scitranslmed.aab1803.

PMID: 26537256

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.

Burkhart C, Fleyshman D, Kohrn R, Commane M, Garrigan J, Kurbatov V, Toshkov I, Ramachandran R, Martello L, Gurova KV.

Oncotarget. 2014 Nov 30;5(22):11038-53.

PMID: 25402820  Free PMC Article

Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells.

Safina A, Garcia H, Commane M, Guryanova O, Degan S, Kolesnikova K, Gurova KV.

Cell Cycle. 2013 Aug 1;12(15):2423-34. doi: 10.4161/cc.25452. Epub 2013 Jun 28.

PMID: 23839038  Free PMC Article

Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.

Garcia H, Miecznikowski JC, Safina A, Commane M, Ruusulehto A, Kilpinen S, Leach RW, Attwood K, Li Y, Degan S, Omilian AR, Guryanova O, Papantonopoulou O, Wang J, Buck M, Liu S, Morrison C, Gurova KV.

Cell Rep. 2013 Jul 11;4(1):159-73. doi: 10.1016/j.celrep.2013.06.013. Epub 2013 Jul 3.

PMID: 23831030  Free Article

Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.

Koman IE, Commane M, Paszkiewicz G, Hoonjan B, Pal S, Safina A, Toshkov I, Purmal AA, Wang D, Liu S, Morrison C, Gudkov AV, Gurova KV.

Cancer Prev Res (Phila). 2012 Aug;5(8):1025-35. doi: 10.1158/1940-6207.CAPR-11-0529. Epub 2012 Jun 11.

PMID: 22689915  Free Article

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells.

Garcia H, Fleyshman D, Kolesnikova K, Safina A, Commane M, Paszkiewicz G, Omelian A, Morrison C, Gurova K.

Oncotarget. 2011 Oct;2(10):783-96.

PMID: 21998152  Free PMC Article

Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.

Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV, Gurova KV.

Sci Transl Med. 2011 Aug 10;3(95):95ra74. doi: 10.1126/scitranslmed.3002530.

PMID: 21832239  Free Article

Inflammation and p53: A Tale of Two Stresses.

Gudkov AV, Gurova KV, Komarova EA.

Genes Cancer. 2011 Apr;2(4):503-16. doi: 10.1177/1947601911409747.

PMID: 21779518 Free PMC Article

Inhibition of encephalomyocarditis virus and poliovirus replication by quinacrine: implications for the design and discovery of novel antiviral drugs.

Gasparian AV, Neznanov N, Jha S, Galkin O, Moran JJ, Gudkov AV, Gurova KV, Komar AA.

J Virol. 2010 Sep;84(18):9390-7. doi: 10.1128/JVI.02569-09. Epub 2010 Jul 14.

PMID: 20631142  Free PMC Article

New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents.

Gurova K.

Future Oncol. 2009 Dec;5(10):1685-704. doi: 10.2217/fon.09.127. Review.

PMID: 20001804  Free PMC Article

Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer.

Narizhneva NV, Tararova ND, Ryabokon P, Shyshynova I, Prokvolit A, Komarov PG, Purmal AA, Gudkov AV, Gurova KV.

Cell Cycle. 2009 Dec 15;8(24):4155-67. Epub 2009 Dec 13.

PMID: 19946220  Free PMC Article

Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.

Neznanov N, Gorbachev AV, Neznanova L, Komarov AP, Gurova KV, Gasparian AV, Banerjee AK, Almasan A, Fairchild RL, Gudkov AV.

Cell Cycle. 2009 Dec;8(23):3960-70. Epub 2009 Dec 25.

PMID: 19901558  Free PMC Article

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways.

Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV, Gurova KV.

Oncogene. 2009 Feb 26;28(8):1151-61. doi: 10.1038/onc.2008.460. Epub 2009 Jan 12.

PMID:  19137016

Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity.

Tararova ND, Narizhneva N, Krivokrisenko V, Gudkov AV, Gurova KV.

Prostate. 2007 Dec 1;67(16):1801-15.

PMID: 17935158

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.

Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E, Khodyakova AV, Ganapathi R, Ganapathi M, Tararova ND, Bosykh D, Lvovskiy D, Webb TR, Stark GR, Gudkov AV.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17448-53. Epub 2005 Nov 15.

PMID: 16287968 Free PMC Article

p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.

Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV.

Cancer Res. 2004 Mar 15;64(6):1951-8.

PMID: 15026329    Free Article

Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells.

Gurova KV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Cohen MB, Gudkov AV.

Cancer Res. 2003 Jun 1;63(11):2905-12.

PMID: 12782597

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